KMID : 0356620070220020000
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Journal of Korean Society of Endocrinology 2007 Volume.22 No. 2 p.0 ~ p.0
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A Case of Pituitary Metastasis of Breast Cancer Presenting as Diabetes Insipidus and Panhypopituitarism
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Kwak Jae-Wuk
Lee Seung-Hwan Yoon Kun-Ho Cha Bong-Yun Son Ho-Young Cho Jae-Hyoung Jie Byoung-Soo Kwon Hyeok-Sang Hong Sun-Hwa Kim Ji-Hyun
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Abstract
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Metastasis to the pituitary gland from systemic cancer is a rare condition. The breast and lung are the most common sites of primary tumor metastasis. Pituitary metastasis may present with diabetes insipidus, cranial nerve palsy and hypopituitarism, and diabetes insipidus is the most frequent symptom at presentation. We report here on a 44 year-old woman with pituitary metastasis from breast cancer, and she developed central diabetes insipidus and hypopituitarism. The clinical diagnosis was made by performing a water deprivation test, a combined pituitary test and a MRI brain scan, and the latter showed metastatic tumor in the pituitary gland with invasion of the pituitary stalk. Symptomatic relief was obtained with administration of desmopressin; the urine osmolarity was increased with this treatment. We report here on a case of pituitary metastasis from breast cancer and the patient developed central diabetes insipidus and hypopituitarism. We also include a review of the relevant literature.
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KEYWORD
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Breast cancer, Central diabetes insipidus, Panhypopituitarism, Pituitary metastasis
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